Ketamine differs significantly from MDMA and psilocybin, which are primarily involved in enhancing emotional empathy and altering consciousness, respectively.

Ketamine offers quick, dissociative experiences and is legally used in clinical settings, impacting the glutamate system. In contrast, MDMA focuses on emotional connections, useful in PTSD treatment, while psilocybin provides lengthy, introspective experiences, both primarily influencing the serotonin system and still under clinical investigation for various mental health treatments.

Read more about MDMA and ketamine here.

Read more about psilocybin and ketamine here.