Most standard drug tests, including 5-panel and 10-panel screenings, do not test for ketamine. However, specialized tests are available that can specifically detect ketamine use.

The detection window for ketamine can vary greatly from person to person. For many individuals, ketamine may clear from the system within 12 hours, but in some cases, it can take up to one or even two weeks for all traces to become undetectable in a drug test.